Omega-3 Fatty Acids: An Essential Contribution (2024)

The human body can make most of the types of fats it needs from other fats or carbohydrates. That isn’t the case for omega-3 polyunsaturated fatty acids (also called omega-3 fats and n-3 fats). These are essential fats—the body can’t make them from scratch but must get them from food. Foods high in omega-3 include certain fish and seafood, some vegetable oils, nuts (especially walnuts), flax seeds, and leafy vegetables.

What makes omega-3 fats special? They are needed to build cell membranes throughout the body and affect the function of the cell receptors in these membranes. They also provide the starting point for making hormones that regulate blood clotting, contraction and relaxation of artery walls, and inflammation. In addition, they can bind to receptors in cells that regulate genetic function. Due to these effects, omega-3 fats can help prevent heart disease and stroke, may help control lupus, eczema, and rheumatoid arthritis, and may play protective roles in cancer and other conditions. [1]

Types of Omega-3s

There are two main types of omega-3 fats that have essential roles in human health:

EPA and DHA: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) come mainly from cold-water fish, so they are sometimes called marine omega-3s. Salmon, mackerel, tuna, herring, and sardines contain high amounts of EPA/DHA. EPA and DHA can be made from another omega-3 fat called alpha-linoleic acid (ALA), so they are more accurately termed “conditionally essential” fats. But because the conversion from ALA to EPA/DHA may not be sufficiently efficient, EPA/DHA are best obtained directly from food sources.
ALA: Alpha-linolenic acid (ALA), the most common omega-3 fatty acid in most Western diets, is found in plant oils (especially canola, soybean, flax), nuts (especially walnuts), chia and flax seeds, leafy vegetables, and some animal fats, especially from grass-fed animals. ALA is a true essential fat because it cannot be made by the body, and is needed for normal human growth and development. It can be converted into EPA and DHA, but the conversion rate is limited so we are still uncertain whether ALA alone can provide optimal intakes of omega-3 fatty acids. [1]

Omega-3 Fats and Health

The strongest evidence for a beneficial effect of omega-3 fats has to do with heart disease. These fats appear to help the heart beat at a steady clip and not veer into a dangerous or potentially fatal erratic rhythm. [2] Such arrhythmias cause most of the 500,000-plus cardiac deaths that occur each year in the United States. Omega-3 fats also lower blood pressure and heart rate, and improve blood vessel function. At higher doses, they lower triglycerides and may ease inflammation, which plays a role in the development of atherosclerosis. [2]

Given the wide-ranging importance of marine omega-3 fatty acids, it is important to eat fish or other seafood 1-2 times a week, particularly fatty (dark meat) fish that is richer in EPA and DHA. [3] This is especially important for women who are pregnant or hoping to become pregnant and nursing mothers. From the third trimester until the second year of life, a developing child needs a steady supply of DHA to form the brain and other parts of the nervous system as DHA is the most abundant fatty acid in the brain. Many women shy away from eating fish because of concerns that mercury and other possible contaminants might harm their babies, [4] yet the evidence for harm from lack of omega-3 fats is far more consistent, and a balance of benefit vs. risk is easily obtained by limiting intake of the types of fish higher in mercury. (To learn more about the controversy over contaminants in fatty fish, read Fish: Friend or Foe.)

Researchers are also looking at the effects of marine and plant omega-3 fats on prostate cancer. Results from the Health Professionals Follow-up Study and others show that men whose diets are rich in EPA and DHA (mainly from fish and seafood) are less likely to develop advanced prostate cancer than those with low intakes of EPA and DHA. [5] At the same time, some studies show an increase in prostate cancer and advanced prostate cancer among men with high intakes of ALA (mainly from supplements). However, this effect is inconsistent. In the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, for example, there was no link between ALA intake and early, late, or advanced prostate cancer. [6] Also, in a recent analysis, ALA intake was not associated with higher risk of prostate cancer after about 2005. [7] This is consistent with concerns that partial hydrogenation of ALA in vegetable oils was responsible for the increase in prostate cancer; partial hydrogenation was greatly reduced after 2005 as part of efforts to reduce consumption of trans fats.

Unlike EPA/DHA, there is much less research on the health benefits of ALA. Though part of the health benefits of ALA may be attributed to its conversion to EPA/DHA, ALA alone may offer modest protection against cardiovascular disease and type 2 diabetes. [8] However, more observational studies and clinical trials are needed. ALA is an important source of omega-3 fats for those who have a fish allergy or who eat a vegan diet.

Can’t I just take a fish oil pill?

If you don’t eat fish, is taking a supplement just as good? Fish oil pills contain both EPA and DHA. Research strongly supports that eating a diet with fatty fish weekly provides protection from cardiovascular disease. However, many large clinical trials have not shown that taking omega-3 supplements provide the same protection. [1,9] There may be a threshold of benefit, in which a certain amount of omega-3 might be protective, but higher dosages such as found in supplements may not further reduce risk. Another reason could be the increased use of highly effective statin medications, which might outshine any modest benefit provided from omega-3 supplements.

A scientific advisory from the American Heart Association reviewed the results of large randomized controlled trials studying the effects of marine-based omega-3 supplements (e.g., fish oil) on cardiovascular disease. [10] The review included the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardio (GISSI Prevention Trial), Japan EPA Lipid Intervention Study (JELIS), Effect of Omega 3-Fatty Acids on the Reduction of Sudden Cardiac Death After Myocardial Infarction Trial (OMEGA), Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation Trial (OPERA), Outcome Reduction With Initial Glargine Intervention Trial (ORIGIN), and Vitamin D and Omega-3 Trial (VITAL). [10-12] The authors of the advisory observed that the earlier trials showed benefit in reducing cardiac deaths, but not later studies. This could be because more people were consuming fatty fish rich in omega-3 during the recent trials, so that taking supplements did not offer more benefit. Another reason is that the use of statins, beta-blockers, and other heart medications were used in more patients in later trials, so that any benefit of taking omega-3 supplements was decreased. However, the authors stated that because omega-3 supplements are relatively safe and the review showed a modest 10% reduction in deaths from heart disease, they felt that using these supplements was reasonable for people with existing heart disease. However, there was not enough evidence to recommend supplements for the prevention of cardiovascular diseases.

The Food and Drug Administration specifies that the labels of dietary supplements should not recommend a daily intake of EPA and DHA higher than 2000 mg due to lack of evidence. For people with heart disease, the American Heart Association (AHA) recommends 1000 mg daily of EPA and DHA, preferably from fish, but supplements can be considered in consultation with a physician. In specific cases, such as to lower triglycerides, the AHA recommends 2000–4000 mg daily of EPA and DHA under a doctor’s supervision.

An alternative to fish oil is algal oil, derived from algae, the omega-3-rich ocean plants eaten by small marine life that is consumed by larger fatty fish. Algal oil contains mostly DHA, and although costlier than fish oil supplements, it is vegan and more sustainably produced without reliance on marine fishing. A review of randomized controlled trials found that algal oil supplementation may help to reduce triglycerides in people without established heart disease. [13]

Omega-3 supplements can act as a mild blood thinner and may increase the risk of bleeding. Inform your doctor if you begin using these supplements as they may also interact with some medications, especially blood thinners.

Is grass-fed beef a good source of omega-3 fats?

Prior to 1950, cattle were typically allowed to pasture and consume a diet of mostly grass. As demands for production increased, cattle were instead fed high-calorie grains made from soy or corn that also created a desirable marbling of the meat from the higher fat content. Today, most cows in the U.S. are still generally fed a grain-based diet; to further speed growth they may be given growth hormone and are restricted in movement.

One might imagine that cows fed primarily grass would be exposed to a more natural habitat of grazing freely and consuming native vegetation, high in nutrients and omega-3 fats. However, the term “grass-fed” is not a regulated term and does not always indicate that cattle are allowed to graze in pastures. They may simply be fed grass or vegetation in a confined space. The United States Department of Agriculture’s Agricultural Marketing Service offers a voluntary certification that specifies that cattle are fed only grass and forage (or hay and alfalfa during low pasture growth) and no grain or grain byproducts during their lifetime. [14]

Regardless if cattle are grain or grass-fed, the majority of fat in the beef is saturated, and the amount of total saturated fat is similar regardless of feeding type. The ratio of saturated to unsaturated fat is also similar for grain or grass-fed cattle, but generally grass-fed beef is leaner with less total fat. [14]

Among grass-fed cows, the amount of omega-3 can vary by types of pasture used for grazing and by the age and breed, as genetics play a role in how fat is stored. Beef from grass-fed cows contains slightly higher levels of omega-3 fat than grain-fed, mainly as ALA (different from the EPA/DHA found in fish). [15] But there is little comparison, as the amount of omega-3 in fatty fish is about 10 times the amount in grass-fed beef. Even plant foods that contain ALA generally offer higher amounts than grass-fed beef. This is represented in the table below, which compares 3 ounces of beef, salmon, and walnuts. Even a more typical 1 ounce serving of walnuts provides over 2500 mg of ALA—about 30 times the amount in a 3 ounce serving of grass-fed beef. Therefore grass-fed beef, though a source of ALA, is not a significant contributor of omega-3 fat in our diets.

Food (serving size: 3 oz/85 g)	ALA (mg)	EPA (mg)	DHA (mg)	Saturated Fat (g)
Ground Beef, grass fed, raw, 85% lean / 15% fat¹	87 mg	9 mg	0 mg	6.75 g
Ground Beef, raw, 85% lean / 15% fat²	35 mg	1.7 mg	0 mg	4.86 g
Salmon (Atlantic), farmed, raw³	126 mg	733 mg	935 mg	2.59 g
Salmon (Atlantic), wild, raw⁴	251 mg	273 mg	952 mg	0.83 g
Walnuts, raw⁵	7718 mg	0 mg	0 mg	5.21 g

Source: 1, 2, 3, 4, 5 via USDA National Nutrient Database for Standard Reference, Legacy (2018).

The Omega-3 to Omega-6 Ratio: Separating Claims from the Evidence

Most Americans take in far more of another essential fat—omega-6 fats—than they do omega-3 fats. Like omega-3 fats, omega-6 fats are a critical part of the structure of every cell of our body and are building blocks for hormones that regulate inflammation, narrowing of blood vessels, and blood clotting. Normally, these are important functions that protect the body from injury and infection, but a popular claim is that an excess intake of omega-6 fats can over-stimulate these functions, causing more harm than benefit. In addition, because omega-3 and omega-6 fats compete for the same enzymes to produce other fatty acids, it is believed that eating an excess of one type may interfere with the metabolism of the other, thereby reducing its beneficial effects. [15]

Some researchers have proposed that a higher intake of omega-6 fats compared with omega-3 fats (also referred to as the omega-6/omega-3 ratio) could contribute to the development of chronic health conditions, like cardiovascular disease and cancer, but this has not been supported by evidence in humans. [1,16] Very consistently, carefully controlled feeding studies do not show that omega-6 fats increase inflammatory factors. [17]

Many studies and trials in humans support cardiovascular benefit of omega-6 fats. In the Health Professionals Follow-up Study, the ratio of omega-6 to omega-3 fats wasn’t linked with heart disease risk because both of these fats were beneficial. [18] In a large prospective study of men and women who were free of cardiovascular disease, cancer, and diabetes at the start of the study, the highest intakes of omega-6 fats were more strongly linked with lower death rates from these diseases than intakes of omega-3 fats. [19]

There is no question that many Americans could benefit from increasing their intake of omega-3 fats, but there is also evidence that omega-6 fats reduce cardiovascular risk factors and heart disease. Thus, the omega-6/omega-3 ratio is not a useful indicator of the healthfulness of a food or diet. Like many essential nutrients, it is possible that too much can cause problems. However in the U.S. diet, we have not been able to find individuals or groups who are consuming excessive amounts of omega-6 fatty acids.

What is conjugated linoleic acid (CLA)?

This is a type of omega-6 fat found naturally in dairy, beef, and vegetable oils. It is also a popular dietary supplement, produced by chemically changing the structure of polyunsaturated vegetable oils. CLA supplements have been researched as a weight loss aid by reducing body fat; however findings have conflicted. Some studies show a modest short-term weight loss while others show no weight changes. Some reported negative side effects include loose stools and fatty liver that may occur when taken in high dosages in supplements.

Ask the expert: Omega-3 fatty acids
Different Dietary Fat, Different Risk of Mortality

References

NIH Office of Dietary Supplements. Omega-3 Fatty Acids. https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/ Accessed May 17, 2018.
Leaf A. Prevention of sudden cardiac death by n-3 polyunsaturated fatty acids. Journal of Cardiovascular Medicine. 2007 Sep 1;8:S27-9.
Rimm EB, Appel LJ, Chiuve SE, Djoussé L, Engler MB, Kris-Etherton PM, Mozaffarian D, Siscovick DS, Lichtenstein AH. Seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease: a science advisory from the American Heart Association. Circulation. 2018 Jul 3;138(1):e35-47.
Oken E, Kleinman KP, Berland WE, Simon SR, Rich-Edwards JW, Gillman MW. Decline in fish consumption among pregnant women after a national mercury advisory. Obstetrics & Gynecology. 2003 Aug 1;102(2):346-51.
Leitzmann MF, Stampfer MJ, Michaud DS, Augustsson K, Colditz GC, Willett WC, Giovannucci EL. Dietary intake of n− 3 and n− 6 fatty acids and the risk of prostate cancer. The American journal of clinical nutrition. 2004 Jul 1;80(1):204-16.
Koralek DO, Peters U, Andriole G, Reding D, Kirsh V, Subar A, Schatzkin A, Hayes R, Leitzmann MF. A prospective study of dietary alpha-linolenic acid and the risk of prostate cancer (United States). Cancer Causes & Control. 2006 Aug;17:783-91.
Wu J, Wilson KM, Stampfer MJ, Willett WC, Giovannucci EL. A 24‐year prospective study of dietary α‐linolenic acid and lethal prostate cancer. International journal of cancer. 2018 Jun 1;142(11):2207-14.
Rajaram S. Health benefits of plant-derived α-linolenic acid. The American journal of clinical nutrition. 2014 Jul 1;100(suppl_1):443S-8S.
Tummala R, Ghosh RK, Jain V, Devanabanda AR, Bandyopadhyay D, Deedwania P, Aronow WS. Fish oil and cardiometabolic diseases: recent updates and controversies. The American journal of medicine. 2019 Oct 1;132(10):1153-9.
Siscovick DS, Barringer TA, Fretts AM, Wu JH, Lichtenstein AH, Costello RB, Kris-Etherton PM, Jacobson TA, Engler MB, Alger HM, Appel LJ. Omega-3 polyunsaturated fatty acid (fish oil) supplementation and the prevention of clinical cardiovascular disease: a science advisory from the American Heart Association. Circulation. 2017 Apr 11;135(15):e867-84.
GISSI-Prevenzione Investigators. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. The Lancet. 1999 Aug 7;354(9177):447-55.
Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, Oikawa S, Sasaki J, Hishida H, Itakura H, Kita T. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. The Lancet. 2007 Mar 31;369(9567):1090-8.
Bernstein AM, Ding EL, Willett WC, Rimm EB. A meta-analysis shows that docosahexaenoic acid from algal oil reduces serum triglycerides and increases HDL-cholesterol and LDL-cholesterol in persons without coronary heart disease. The Journal of nutrition. 2012 Jan 1;142(1):99-104.
Van Elswyk ME, McNeill SH. Impact of grass/forage feeding versus grain finishing on beef nutrients and sensory quality: The US experience. Meat science. 2014 Jan 1;96(1):535-40.
Daley CA, Abbott A, Doyle PS, Nader GA, Larson S. A review of fatty acid profiles and antioxidant content in grass-fed and grain-fed beef. Nutrition journal. 2010 Dec;9(1):1-2.
Willett WC. The role of dietary n-6 fatty acids in the prevention of cardiovascular disease. Journal of Cardiovascular Medicine. 2007 Sep 1;8:S42-5.
Su H, Liu R, Chang M, Huang J, Wang X. Dietary linoleic acid intake and blood inflammatory markers: a systematic review and meta-analysis of randomized controlled trials. Food & function. 2017;8(9):3091-103.
Mozaffarian D, Ascherio A, Hu FB, Stampfer MJ, Willett WC, Siscovick DS, Rimm EB. Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation. 2005 Jan 18;111(2):157-64.
Wang DD, Li Y, Chiuve SE, Stampfer MJ, Manson JE, Rimm EB, Willett WC, Hu FB. Association of specific dietary fats with total and cause-specific mortality. JAMA internal medicine. 2016 Aug 1;176(8):1134-45.

Terms of Use

The contents of this website are for educational purposes and are not intended to offer personal medical advice. You should seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website. The Nutrition Source does not recommend or endorse any products.